Title: A multi-wavelength view of the ISM in Nearby Galaxies Abstract: We have developed an objective, automated method to compare multi-wavelength images based on 2–D pixel-by-pixel cross-correlations. We introduced a measure for the degree of correlation, Ccoef, which takes values from 1 (perfect correlation) to -1 (perfect anti-correlation). This we subsequently applied to NGC 2403, in a pilot project using HI data from THINGS, 8um, 24um, 70um and Halpha; maps from SINGS, and FUV data from NGS. We produce spatially resolved cross-correlation maps, on scales of 250 pc to 1000 pc and radial profiles of the cross-correlation coefficients. To date no practical method has been deployed to compare maps across the electromagnetic spectrum of galaxies while preserving spatial information. I will present the results of our method and discuss its possible applications to the wealth of high resolution maps that have and will become available based on observations with the new generation of telescopes.