Title: A Statistical comparison of the near-IR emission with the Halpha emission from the HII regions of NGC 4321 and of NGC 4736 Abstract: We report on our ongoing project "Statistical studies of HII regions in the nearby extragalaxies". We measure the Halpha luminosities, and the near IR luminosities in the 4 Spitzer passbands, of a complete sample of 78 and 74 isolated luminous HII regions in the grand design galaxy NGC 4321(M100) and NGC 4736 respectively. We find a strong, and expected positive correlation between the total IR luminosity and the Halpha luminosity, but no significant correlation between the luminosity and the IR colour temperature of the regions. We draw appropriate conclusions.