Title: Anatomy of an X-ray detected cluster at z = 2: low metallicities and enhanced specific star formation rates in star-forming galaxies. Abstract: The most distant spectroscopically confirmed cluster known to date, CL J1449+0856 at z=2, represents a unique laboratory to study galaxy evolution in dense environments at high redshifts and, in the past few years, a systematic multiwavelength campaign allowed us to test the current understanding of environment-driven processes in galaxies. Surprisingly, recent Subaru and HST spectroscopic follow-ups revealed lower metallicities and higher sSFRs in cluster star-forming galaxies than in mass-matched field counterparts. This somewhat unexpected behaviour can be possibly due to an enhanced accretion of pristine gas from the environment and/or facilitated by recent or ongoing merging activity, something probably linked to the recent assembly of its dark matter halo. The further discovery of a giant Lya halo residing in the cluster core in a narrow-band imaging follow-up and the presence of very strong diffuse light in the near-IR support the idea of a physical connection between Mpc- scale environment and galaxy evolution at the peak of cosmic star formation history at z~2. Forthcoming KMOS observations will allow us to test different gas-enrichment scenarios constraining metallicity gradients, while partial overlap with our ongoing ALMA observation will shed light on the molecular gas content of these objects.