STIS's internal buffer stores the data in a 16-bit per pixel format. This format imposes a maximum of 65,536 data numbers per pixel. For the MAMA detectors this number is equivalent to a limit on the total number of photons per pixel which can be accumulated in a single exposure. The CCD full well (and not the 16-bit buffer format) limits the photons per pixel that can accumulate without saturating in a single exposure, for both GAIN=1 and GAIN=4 observations.